Mescaline is a naturally occurring psychedelic that comes from the Mexican peyote cactus (Lophohora williamsii) and the San Pedro cactus found in Peru and Ecuador.2

Mescaline can be a powder, tablet, capsule or liquid. Peyote buttons can be chewed to gain the desired effects.2

How is mescaline used?

The fresh or dried buttons are chewed or soaked in water to produce a liquid. Peyote buttons can also be ground into a white powder that can be placed inside capsules to be swallowed or smoked with cannabis or tobacco. Mescaline has a bitter taste, so it is put into capsules to avoid the taste.3

Effects of mescaline

Use of any drug can have risks. It’s important to be careful when taking any type of drug.

Psychedelics affect everyone differently, based on:

  • size, weight and health
  • whether the person is used to taking it
  • whether other drugs are taken around the same time
  • the amount taken
  • the strength of the drug (varies from batch to batch)
  • the environment (where the drug is taken).

Mescaline affects everyone differently, but effects may include:

  • euphoria
  • increased energy
  • perceptual distortions, such as bright lights or geometric patterns
  • space and time distortion
  • difficulty concentrating, thinking and maintaining attention
  • increased blood pressure and heart rate
  • intense nausea and vomiting
  • reduced appetite
  • increased body temperature and sweating.2, 4

According to anecdotal reports, the effects of mescaline take approximately 45-90 minutes to commence and can last between 9-14 hours.4

Impact of mood and environment

Drugs that affect a person’s mental state (psychoactive drugs) can also have varied effects depending on a person’s mood (often called the ‘set’) or the environment they are in (the ‘setting’).

Set is a person’s state of mind, previous encounters with psychedelic drugs, and expectations of what’s going to happen. For example, feelings of stress or anxiety before using mescaline may result in an unpleasant experience (bad trip).5

Setting is the environment in which someone consumes mescaline – whether it’s known and familiar, who they’re with, if they’re indoors or outdoors, the type of music being played and the light. For example, using mescaline in a calm, quiet and relaxed environment can lead to, or contribute to, a pleasant experience but being in a noisy, crowded place may result in a negative experience.5

Being in a good state of mind, with trusted friends and a safe environment before taking mescaline reduces the risk of having a ‘bad’ trip.

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